Peptidele hormonale utilizate in culturism sunt un fel de substante despre care se spune ca sunt varianta mai sigura si legala a steroizilor anabolizanti si androgeni.
In ultimii ani vanzarile de astfel de peptide au explodat, uneori si datorita unor producatori de suplimente care le-au folosit si au pretins ca pot creste masa musculara, pot imbunatati arderile grasimilor si pot face toate astea in mod natural si sigur. Este adevarat? Sunt peptidele hormonale la fel ca steroizii? Mai toate plusurile dar fara efectele secundare negative? In continuare gasesti raspunsurile.
Ce sunt peptidele hormonale?
Termenul de "peptida" se refera la orice molecula alcatuita din 2 - 50 aminoacizi uniti intre ei prin legaturi peptidice. Peptidele exista in mod natural in corpul uman si al animalelor dar si in plante cu continut de proteine. Pot fi si sintetizate artificial in laborator.
Cand vorbim de peptidele hormonale din culturism ne referim la cele sub forma de pudra sau injectabile care stimuleaza secretia de hormon de crestere (HGH), numite si peptide secretagog al hormonului de crestere. Acestea stimuleaza hipotalamusul sa secrete mai mult hormon de crestere.
Care sunt beneficiile peptidelor hormonale din culturism?
Sporirea nivelurilor de hormon de crestere este ceva foarte dorit de culturisti pentru ca mobilizeaza grasimea corporala, ceea ce inseamna ca ajuta la eliberarea acizilor grasi stocati in celulele grase, facand mai usoara arderea grasimilor si conservarea masei musculare. Hormonul de crestere mareste si secretia de IGF-1, care mareste masa musculara si sporeste si mai mult arderile grasimilor.
Asadar, logica este ca daca folosesti peptide hormonale de tipul secretagog vei slabi si vei acumula grasime in acelasi timp. Si cum este legal sa cumperi astfel de peptide (datorita unei chichite care tine de etichetare, o sa vorbim si despre asta) si sunt considerate relativ sigure, sunt vazute ca o alternativa mai sanatoasa la steroizii anabolizanti.
Asta presupunand ca functioneaza, ceea ce este discutabil.
Exista dovezi solide ca mecanismul prin care imbunatatesc compozitia corpului exista si functioneaza, dar nu exista multe dovezi ca functioneaza asa cum spera multi culturisti.
De exemplu, cercetari facute la Universitatea din Chile, la Centrul Medical pentru Copii Schneider din Israel si la Universitatea din Washington, arata ca peptidele hormonale sunt eficiente in cresterea nivelurilor de HGH si IGF-1 la copii mici prepubertate. Asta arata ca peptidele hormonale sunt de un mare ajutor pentru ca toti copiii mici sa cresca la fel de inalti ca ceilalti copii, nu sunt dovezi concrete ca pot ajuta un adult de 35 de ani sa slabeasca si sa construiasca masa musculara.
Alte studii arata ca peptidele hormonale au efecte pozitive in randul varstnicilor si celor infirmi. Au fost studii in care pacientii care sufereau de cancer pulmonar si luau peptide hormonale secretagoge cresteau mai bine in greutate decat cei care nu luau. La fel, masa musculara crestea mai mult la batranii care se recupereau dupa fracturi. Din nou, este dificil sa vezi daca aceste studii se aplica si tinerilor sanatosi.
Sunt si studii care arata ca aceste peptide pot ajuta obezii sa slabeasca, dar rezultatele nu se aplica neaparat si celor cu greutati mai mici, pentru ca perosanele obeze tind sa aibe o secretie deficitara a hormonului de crestere, asa ca raspunsul la tratament nu este mereu la fel si la persoanele cu greutati sanatoase.
Au existat si cateva studii care au analizat efectele asupra unor persoane sanatoase si cu niveluri normale de grasime, si au aratat efecte pozitive in general, dar si aceste studii au fost facute pe esantioane mici (numar mic de participanti) si unele au avut anumite erori de organizare care fac dificila extrapolarea lor la omul de rand care merge la sala.
Ar trebui sa folosesti peptide hormonale?
Asta depinde de tine. Dar retine ca nu exista dovezi concrete ca te pot ajuta, daca esti un impatimit de fitness care merge la sala regulat, are grija ce mananca si are in general un stil de viata sanatos. Dupa cum am spus, studiile sunt promitatoare, dar nu exista dovezi definitive ca te pot ajuta.
Argumentele teoretice par solide, si exista multe povesti de succes ale celor care au folosit peptidele hormonale, dar toate acestea nu sunt dovezi concrete ca functioneaza.
Si cel mai important, inca nu exista date pe termen lung privind eficienta si efectele secundare. Studiile arata ca nu exista efecte adverse daca iei peptide hormonale cateva saptamani sau luni, dar nu se stie ce se intampla cand le iei mai multi ani, chiar daca in cure separate, si nici daca exista efecte secundare care apar mai tarziu (precum cancer, boli de inima, etc.).
Exista si efecte nedorite de la peptide, doar ca nu grave. Multe studii au raportat efecte secundare precum transpiratii mai abundente, bufeuri de caldura si inrosirea pielii, dureri musculare medii, retentia de fluide, somn perturbat si cresteri ale nivelurilor de cortizol si prolactine.
Unele astfel de peptide au ca efecte secundare cresterea apetitului si scaderea sensibilitatii la insulina, ambele putand opri efortul de a slabi.
Si legalitatea peptidelor hormonale este dubioasa. Este interzisa vanzarea de peptide hormonale ca si suplimente dar permisa vanzarea lor ca "substante de cercetare" sau "nu pentru consumul uman".
Teoretic, singurii care ar avea voie sa cumpere peptide ar fi cercetatorii care fac experimente cu ele. Desigur, majoritatea peptidelor hormonale vandute online nu ajung in laboratoare, ci la culturisti, sportivi si pasionati de fitness care incearca sa devina mai definiti si masivi.
Asadar piata peptidelor hormonale este dubioasa in ansamblul ei si nu stii sigur ce cumperi si nici macar ce efecte va avea.
Referinte
- Forbes, J., & Krishnamurthy, K. (2021). Biochemistry, Peptide. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK562260/
- Chakrabarti, S., Guha, S., & Majumder, K. (2018). Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities. Nutrients, 10(11). https://doi.org/10.3390/NU10111738
- Mada, S. B., Ugwu, C. P., & Abarshi, M. M. (2019). Health Promoting Effects of Food-Derived Bioactive Peptides: A Review. International Journal of Peptide Research and Therapeutics 2019 26:2, 26(2), 831–848. https://doi.org/10.1007/S10989-019-09890-8
- Bowers, C. Y., Granda, R., Mohan, S., Kuipers, J., Baylink, D., & Veldhuis, J. D. (2004). Sustained elevation of pulsatile growth hormone (GH) secretion and insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women. The Journal of Clinical Endocrinology and Metabolism, 89(5), 2290–2300. https://doi.org/10.1210/JC.2003-031799
- Gertz, B. J., Barrett, J. S., Eisenhandler, R., Krupa, D. A., Wittreich, J. M., Seibold, J. R., & Schneider, S. H. (1993). Growth hormone response in man to L-692,429, a novel nonpeptide mimic of growth hormone-releasing peptide-6. The Journal of Clinical Endocrinology and Metabolism, 77(5), 1393–1397. https://doi.org/10.1210/JCEM.77.5.8077339
- Jaffe, C. A., Ho, P. J., Demott-Friberg, R., Bowers, C. Y., & Barkan, A. L. (1993). Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men. The Journal of Clinical Endocrinology and Metabolism, 77(6), 1641–1647. https://doi.org/10.1210/JCEM.77.6.7903313
- Leal-Cerro, A., Garcia, E., Astorga, R., Casanueva, F. F., & Dieguez, C. (1995). Growth hormone (GH) responses to the combined administration of GH-releasing hormone plus GH-releasing peptide 6 in adults with GH deficiency. European Journal of Endocrinology, 132(6), 712–715. https://doi.org/10.1530/EJE.0.1320712
- Tuilpakov, A. N., Bulatov, A. A., Peterkova, V. A., Elizarova, G. P., Volevodz, N. N., & Bowers, C. Y. (1995). Growth hormone (GH)-releasing effects of synthetic peptide GH-releasing peptide-2 and GH-releasing hormone (1-29NH2) in children with GH insufficiency and idiopathic short stature. Metabolism: Clinical and Experimental, 44(9), 1199–1204. https://doi.org/10.1016/0026-0495(95)90016-0
- Thomas, A., Kohler, M., Mester, J., Geyer, H., Schänzer, W., Petrou, M., & Thevis, M. (2010). Identification of the growth-hormone-releasing peptide-2 (GHRP-2) in a nutritional supplement. Drug Testing and Analysis, 2(3), 144–148. https://doi.org/10.1002/DTA.120
- Aloi, J. A., Gertz, B. J., Hartman, M. L., Huhn, W. C., Pezzoli, S. S., Wittreich, J. M., Krupa, D. A., & Thorner, M. O. (1994). Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjects. The Journal of Clinical Endocrinology and Metabolism, 79(4), 943–949. https://doi.org/10.1210/JCEM.79.4.7962302
- Gertz, B. J., Barrett, J. S., Eisenhandler, R., Krupa, D. A., Wittreich, J. M., Seibold, J. R., & Schneider, S. H. (1993). Growth hormone response in man to L-692,429, a novel nonpeptide mimic of growth hormone-releasing peptide-6. The Journal of Clinical Endocrinology and Metabolism, 77(5), 1393–1397. https://doi.org/10.1210/JCEM.77.5.8077339
- Bellone, J., Ghizzoni, L., Aimaretti, G., Volta, C., Boghen, M. F., Bernasconi, S., & Ghigo, E. (1995). Growth hormone-releasing effect of oral growth hormone-releasing peptide 6 (GHRP-6) administration in children with short stature. European Journal of Endocrinology, 133(4), 425–429. https://doi.org/10.1530/EJE.0.1330425
- Hersch, E. C., & Merriam, G. R. (2008). Growth hormone (GH)–releasing hormone and GH secretagogues in normal aging: Fountain of Youth or Pool of Tantalus? Clinical Interventions in Aging, 3(1), 121. https://doi.org/10.2147/cia.s3247
- Anderson, L. J., Tamayose, J. M., & Garcia, J. M. (2018). Use of Growth Hormone, IGF-I, and Insulin for Anabolic Purpose: Pharmacological Basis, Methods of Detection, and Adverse Effects. Molecular and Cellular Endocrinology, 464, 65. https://doi.org/10.1016/J.MCE.2017.06.010
- Sigalos, J. T., & Pastuszak, A. W. (2018). The Safety and Efficacy of Growth Hormone Secretagogues. Sexual Medicine Reviews, 6(1), 45. https://doi.org/10.1016/J.SXMR.2017.02.004
- Velloso, C. P. (2008). Regulation of muscle mass by growth hormone and IGF-I. British Journal of Pharmacology, 154(3), 557. https://doi.org/10.1038/BJP.2008.153
- Mericq, V., Cassorla, F., Salazar, T., Avila, A., Iñiguez, G., Bowers, C. Y., & Merriam, G. R. (1998). Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children. The Journal of Clinical Endocrinology and Metabolism, 83(7), 2355–2360. https://doi.org/10.1210/JCEM.83.7.4969
- Laron, Z., Frenkel, J., Deghenghi, R., Anin, S., Klinger, B., & Silbergeld, A. (1995). Intranasal administration of the GHRP hexarelin accelerates growth in short children. Clinical Endocrinology, 43(5), 631–635. https://doi.org/10.1111/J.1365-2265.1995.TB02929.X
- Pihoker, C., Badger, T. M., Reynolds, G. A., & Bowers, C. Y. (1997). Treatment effects of intranasal growth hormone releasing peptide-2 in children with short stature. The Journal of Endocrinology, 155(1), 79–86. https://doi.org/10.1677/JOE.0.1550079
- Currow, D., Temel, J. S., Abernethy, A., Milanowski, J., Friend, J., & Fearon, K. C. (2017). ROMANA 3: a phase 3 safety extension study of anamorelin in advanced non-small-cell lung cancer (NSCLC) patients with cachexia. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 28(8), 1949–1956. https://doi.org/10.1093/ANNONC/MDX192
- Temel, J. S., Abernethy, A. P., Currow, D. C., Friend, J., Duus, E. M., Yan, Y., & Fearon, K. C. (2016). Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials. The Lancet. Oncology, 17(4), 519–531. https://doi.org/10.1016/S1470-2045(15)00558-6
- Takayama, K., Katakami, N., Yokoyama, T., Atagi, S., Yoshimori, K., Kagamu, H., Saito, H., Takiguchi, Y., Aoe, K., Koyama, A., Komura, N., & Eguchi, K. (2016). Anamorelin (ONO-7643) in Japanese patients with non-small cell lung cancer and cachexia: results of a randomized phase 2 trial. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 24(8), 3495–3505. https://doi.org/10.1007/S00520-016-3144-Z
- Bach, M. A., Rockwood, K., Zetterberg, C., Thamsborg, G., Hébert, R., Devogelaer, J. P., Christiansen, J. S., Rizzoli, R., Ochsner, J. L., Beisaw, N., Gluck, O., Yu, L., Schwab, T., Farrington, J., Taylor, A. M., Ng, J., & Fuh, V. (2004). The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture. Journal of the American Geriatrics Society, 52(4), 516–523. https://doi.org/10.1111/J.1532-5415.2004.52156.X
- Adunsky, A., Chandler, J., Heyden, N., Lutkiewicz, J., Scott, B. B., Berd, Y., Liu, N., & Papanicolaou, D. A. (2011). MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. Archives of Gerontology and Geriatrics, 53(2), 183–189. https://doi.org/10.1016/J.ARCHGER.2010.10.004
- Svensson, J., Lönn, L., Jansson, J.-O., Murphy, G., Wyss, D., Krupa, D., Cerchio, K., Polvino, W., Gertz, B., Boseaus, I., Sjöström, L., & Bengtsson, B.-Å. (1998). Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. The Journal of Clinical Endocrinology and Metabolism, 83(2), 362–369. https://doi.org/10.1210/JCEM.83.2.4539
- Höybye, C., Hilding, A., Jacobsson, H., & Thorén, M. (2003). Growth hormone treatment improves body composition in adults with Prader-Willi syndrome. Clinical Endocrinology, 58(5), 653–661. https://doi.org/10.1046/J.1365-2265.2003.01769.X
- Marzullo, P., Marcassa, C., Campini, R., Eleuteri, E., Minocci, A., Sartorio, A., Vettor, R., Liuzzi, A., & Grugni, G. (2007). Conditional cardiovascular response to growth hormone therapy in adult patients with Prader-Willi syndrome. The Journal of Clinical Endocrinology and Metabolism, 92(4), 1364–1371. https://doi.org/10.1210/JC.2006-0600
- Williams, T., Berelowitz, M., Joffe, S. N., Thorner, M. O., Rivier, J., Vale, W., & Frohman, L. A. (1984). Impaired growth hormone responses to growth hormone-releasing factor in obesity. A pituitary defect reversed with weight reduction. The New England Journal of Medicine, 311(22), 1403–1407. https://doi.org/10.1056/NEJM198411293112203
- Cordido, F., Peñalva, A., Peino, R., Casanueva, F. F., & Dieguez, C. (1995). Effect of combined administration of growth hormone (GH)-releasing hormone, GH-releasing peptide-6, and pyridostigmine in normal and obese subjects. Metabolism, 44(6), 745–748. https://doi.org/10.1016/0026-0495(95)90187-6
- Hayashi, S., Okimura, Y., Yagi, H., Uchiyama, T., Takeshima, Y., Shakutsui, S., Oohashi, S., Bowers, C. Y., & Chihara, K. (n.d.). Intranasal Administration of H is-D-Trp-AIa-Trp-D-Phe-LysNH2 (Growth Hormone Releasing Peptide) Increased Plasma Growth Hormone and Insulin-like Growth Factor-I Levels in Normal Men.
- Murphy, M. G., Plunkett, L. M., Gertz, B. J., He, W., Wittreich, J., Polvino, W. M., & Clemmons, D. R. (1998). MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. The Journal of Clinical Endocrinology and Metabolism, 83(2), 320–325. https://doi.org/10.1210/JCEM.83.2.4551
- Helms, E. R., Aragon, A. A., & Fitschen, P. J. (2014). Evidence-based recommendations for natural bodybuilding contest preparation: nutrition and supplementation. Journal of the International Society of Sports Nutrition 2014 11:1, 11(1), 1–20. https://doi.org/10.1186/1550-2783-11-20
- Sardeli, A. V., Komatsu, T. R., Mori, M. A., Gáspari, A. F., & Chacon-Mikahil, M. P. T. (2018). Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis. Nutrients, 10(4). https://doi.org/10.3390/NU10040423
- Nass, R., Pezzoli, S. S., Oliveri, M. C., Patrie, J. T., Harrell, F. E., Clasey, J. L., Heymsfield, S. B., Bach, M. A., Vance, M. L., & Thorner, M. O. (2008). Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults: A Randomized, Controlled Trial. Annals of Internal Medicine, 149(9), 601. https://doi.org/10.7326/0003-4819-149-9-200811040-00003
- Sigalos, J. T., & Pastuszak, A. W. (2018). The Safety and Efficacy of Growth Hormone Secretagogues. Sexual Medicine Reviews, 6(1), 45. https://doi.org/10.1016/J.SXMR.2017.02.004
- Adunsky, A., Chandler, J., Heyden, N., Lutkiewicz, J., Scott, B. B., Berd, Y., Liu, N., & Papanicolaou, D. A. (2011). MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. Archives of Gerontology and Geriatrics, 53(2), 183–189. https://doi.org/10.1016/J.ARCHGER.2010.10.004
- Nass, R., Pezzoli, S. S., Oliveri, M. C., Patrie, J. T., Harrell, F. E., Clasey, J. L., Heymsfield, S. B., Bach, M. A., Vance, M. L., & Thorner, M. O. (2008). Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults: A Randomized, Controlled Trial. Annals of Internal Medicine, 149(9), 601. https://doi.org/10.7326/0003-4819-149-9-200811040-00003
- Mericq, M. V., Cassorla, F., Bowers, C. Y., Avila, A., Gonen, B., & Merriam, G. R. (2003). Changes in appetite and body weight in response to long-term oral administration of the ghrelin agonist GHRP-2 in growth hormone deficient children. Journal of Pediatric Endocrinology & Metabolism : JPEM, 16(7), 981–985. https://doi.org/10.1515/JPEM.2003.16.7.981
- Bach, M. A., Rockwood, K., Zetterberg, C., Thamsborg, G., Hébert, R., Devogelaer, J. P., Christiansen, J. S., Rizzoli, R., Ochsner, J. L., Beisaw, N., Gluck, O., Yu, L., Schwab, T., Farrington, J., Taylor, A. M., Ng, J., & Fuh, V. (2004). The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture. Journal of the American Geriatrics Society, 52(4), 516–523. https://doi.org/10.1111/J.1532-5415.2004.52156.X
- Adunsky, A., Chandler, J., Heyden, N., Lutkiewicz, J., Scott, B. B., Berd, Y., Liu, N., & Papanicolaou, D. A. (2011). MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. Archives of Gerontology and Geriatrics, 53(2), 183–189. https://doi.org/10.1016/J.ARCHGER.2010.10.004
- Huhn, W. C., Hartman, M. L., Pezzoli, S. S., & Thorner, M. O. (1993). Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus. The Journal of Clinical Endocrinology and Metabolism, 76(5), 1202–1208. https://doi.org/10.1210/JCEM.76.5.8496311
- Sigalos, J. T., & Pastuszak, A. W. (n.d.). The Safety and Efficacy of Growth Hormone Secretagogues. https://doi.org/10.1016/j.sxmr.2017.02.004
- Adunsky, A., Chandler, J., Heyden, N., Lutkiewicz, J., Scott, B. B., Berd, Y., Liu, N., & Papanicolaou, D. A. (2011). MK-0677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: a multicenter, randomized, placebo-controlled phase IIb study. Archives of Gerontology and Geriatrics, 53(2), 183–189. https://doi.org/10.1016/J.ARCHGER.2010.10.004
- Stokes, T., Hector, A. J., Morton, R. W., McGlory, C., & Phillips, S. M. (2018). Recent Perspectives Regarding the Role of Dietary Protein for the Promotion of Muscle Hypertrophy with Resistance Exercise Training. Nutrients, 10(2). https://doi.org/10.3390/NU10020180
- Branch, J. D. (2003). Effect of creatine supplementation on body composition and performance: a meta-analysis. International Journal of Sport Nutrition and Exercise Metabolism, 13(2), 198–226. https://doi.org/10.1123/IJSNEM.13.2.198
- Eckerson, J. M., Stout, J. R., Moore, G. A., Stone, N. J., Iwan, K. A., Gebauer, A. N., & Ginsberg, R. (2005). Effect of creatine phosphate supplementation on anaerobic working capacity and body weight after two and six days of loading in men and women. Journal of Strength and Conditioning Research, 19(4), 756–763. https://doi.org/10.1519/R-16924.1
- Bassit, R. A., Pinheiro, C. H. D. J., Vitzel, K. F., Sproesser, A. J., Silveira, L. R., & Curi, R. (2010). Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity. European Journal of Applied Physiology, 108(5), 945–955. https://doi.org/10.1007/S00421-009-1305-1
- Astrup, A., Toubro, S., Cannon, S., Hein, P., Breum, L., & Madsen, J. (1990). Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. The American Journal of Clinical Nutrition, 51(5), 759–767. https://doi.org/10.1093/AJCN/51.5.759
- Astorino, T. A., Rohmann, R. L., & Firth, K. (2008). Effect of caffeine ingestion on one-repetition maximum muscular strength. European Journal of Applied Physiology, 102(2), 127–132. https://doi.org/10.1007/S00421-007-0557-X
- Beck, T. W., Housh, T. J., Schmidt, R. J., Johnson, G. O., Housh, D. J., Coburn, J. W., & Malek, M. H. (2006). The acute effects of a caffeine-containing supplement on strength, muscular endurance, and anaerobic capabilities. Journal of Strength and Conditioning Research, 20(3), 506–510. https://doi.org/10.1519/18285.1
- Ostojic, S. M. (2006). Yohimbine: the effects on body composition and exercise performance in soccer players. Research in Sports Medicine (Print), 14(4), 289–299. https://doi.org/10.1080/15438620600987106
- De Boer, S. F., & Koolhaas, J. M. (2005). 5-HT1A and 5-HT1B receptor agonists and aggression: A pharmacological challenge of the serotonin deficiency hypothesis. European Journal of Pharmacology, 526(1–3), 125–139. https://doi.org/10.1016/j.ejphar.2005.09.065